Description
Product details
MT-2 — Cyclic Melanocortin Receptor Agonist
MT-2 (Melanotan II) is a synthetic cyclic lactam analog of α-melanocyte-stimulating hormone (α-MSH). Structural modifications — including cyclization via a lactam bridge, D-amino acid substitution, and truncation to seven residues — yield a peptide with dramatically enhanced metabolic stability, higher receptor-binding affinity, and broader melanocortin subtype engagement than the native linear hormone.
Mechanism of Action
MT-2 acts as a non-selective agonist across melanocortin receptor subtypes MC1R through MC5R. At MC1R in epidermal melanocytes, it activates the cAMP/PKA/MITF axis to drive eumelanin synthesis via tyrosinase upregulation. MC3R and MC4R engagement in the hypothalamus modulates appetite, energy balance, and central melanocortin signaling — the basis of a large research literature on central melanocortin signaling. The cyclic architecture makes MT-2 resistant to the enzymatic degradation that rapidly inactivates linear α-MSH.
Research Applications
- Melanogenesis and eumelanin synthesis studies
- Melanocortin receptor subtype profiling (MC1R–MC5R)
- UV-independent pigmentation pathway research
- Central appetite regulation and hypothalamic circuits
- Central melanocortin signaling and MC4R receptor research
- Comparative studies with linear and selective MC agonists
Product Specifications
- Quantity: 10mg per vial
- Purity: ≥98% (HPLC verified)
- Molecular Formula: C₅₀H₆₉N₁₅O₉
- Molecular Weight: 1024.2 g/mol
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: Third-party lab tested, COA available on portal
- Actual Tested Value: 9.82mg
For research purposes only. Not for human or veterinary use.
